Archive for July, 2006

Postpartum Psychosis: The Science and the Seeds of Tragedy for Andrea Yates and Family

Monday, July 31st, 2006

What do we know about the cause of postpartum psychosis?

Hormones, especially estrogen, have a significant effect on mood. Estrogen raises serotonin. When estrogen drops precipitously, as it does premenstrually, postpartum, and at the onset of menopause - the brain serotonin levels drop. In women who are sensitive to low serotonin (because of genetics or previous episodes of significant depression) dropping the level will bring on symptoms of depression.

This principle can be demonstrated experimentally. By giving someone a drink of amino acid (from which tryptophan has been removed) the level of brain serotonin will temporarily go down. This is because tryptophan is the amino acid the brain uses to make serotonin. Only people with a vulnerability to becoming clinically depressed will show a depressive response to the serotonin level drop. This phenomenon contributes to premenstrual depression and menopausal (especially perimenopausal) depression.

Think about how dramatically hormone levels drop after child birth. This is why postpartum blues (brief symptoms of mild depression) is extremely common. The postpartum period is the highest risk period for full blown clinical depression.

Post partum psychosis is an extreme form of mood disorder in which underlying genetic vulnerability causes not only depression but a psychotic state. This fortunately only occurs in 1 out of 1000 births.

Psychosis is often confused with delirium. Delirium is a state of severe confusion and disorientation that can be brought on by toxins, severe infections, and many other causes. Every area of functioning is impaired. Psychosis means there is a distortion between conscious reality and external reality.

The most common symptoms of psychosis are hallucinations (seeing things or hearing things that aren’t there) or delusions (beliefs that aren’t true). A person can have one serious delusion that can affect their behavior but can be totally normal in other areas of functioning.

Yates Family PhotoA woman who has had one postpartum psychosis is at a very high risk in any future pregnancies. It was for this reason that Andrea Yates was advised not to have any more children. So why did she and her husband ignore this? I don’t presume to know all the factors that they took into account. But I know she was never diagnosed as bipolar.  And they were never adequately educated about the physiology and medical science that we do have about what causes postpartum depression and psychosis.

Another factor in the Yate’s decision to continue to have children was their faith. They relied more on spiritual experience and counseling with their minister than medical advice. Unfortunately they had come under the influence of an extremist minister, and their medical advice was inadequate and not convincing.

Can they be faulted for not realizing all of this?  I think not. It is not unusual for a person of strong faith to at times feel caught between science on the one side and their faith on the other.

Many centuries ago St. Augustine showed more wisdom in this matter than many of our current experts. He said in effect science and religion aren’t in opposition. They are both ways of looking at and understanding one truth. When science and religion don’t agree we need to discourse and study so that the disagreement can be resolved - without feeling like you have to choose one or the other. Of course not all supposed science is valid and not all ministerial counsel can be trusted. Extremism of any type is dangerous.

What if we faced the truth about Andrea Yates?

Saturday, July 29th, 2006

“They found Andrea Yates not guilty,” my receptionist said to me Wednesday afternoon. I was delighted and surprised. I felt proud to be a Texan. Twelve jurors were able to do the right thing in spite of an almost impossible legal standard complicated by obstacles and hurdles imposed by a system that has the intellectual sophistication of the dark ages. The political powers changed the rules after Hinckley was found not guilty by reason of insanity for shooting President Reagan. Politicians and ultimately judicial officials pander to the vote - that’s the system.

Wednesday night the backlash began. I like Nancy Grace – the popular CNN Headline News Channel’s attorney/program hostess. She is tough but I usually agree with her. She is willing to take on any issue or individual and challenge the system in desperate need of repair. But on her Wednesday night show she was in la la land. She acted like a trial lawyer with their client (in this case the five murdered children) but dehumanized the opposing side, in this case Andrea Yates. Her position was that Andrea Yates was stressed out by taking care of five small kids and being trapped at home all day so she murdered them to make her life easier. Give me a break. Yates immediately called the police, told them what she did, she knew she was going to prison; she probably even thought she would be put to death - this is making your life easier?

On Thursday night I was speaking to a group of physicians and pharmaceutical reps in Lubbock, Texas. I asked, “How many of you are happy with the Andrea Yates verdict?” Only one doctor raised his hand. The overwhelming majority thought she is guilty and should spend the rest of her life in prison.

Then, on Prime Time Thursday night on ABC, they showed one of the prosecution’s “expert witness” psychiatrists interviewing (badgering) Yates on video tape having her retell detail by detail the horrible scenes that will forever torture her mind. He was splitting hairs in an apparent attempt to trap her into telling what he thought was the truth - that she planned and carried out a cold blooded murder of her children because she was tired of the strain of motherhood. What an idiot. He impressed me not as an insightful, empathic physician but as a member of the oldest profession.

On the brighter side, The Dallas Morning News editorial on Thursday morning supported the verdict and noted that they were reversing their position from their earlier support of the guilty verdict. Friday morning the USA Today editorial headline read, “Yates verdict reflects a healthy evolution.” They applaud the new verdict and conclude that “society has come a long way since the acquittal of Hinckley…” They also added that the law needs to come a bit further. I’m afraid it’s going to take more than a bit.

Why is there so much confusion? How can intelligent caring people be so polarized?

I am totally convinced that nothing is going to change until the majority of voting citizens clearly understand the issues and support a separate handling of individuals like Andrea Yates who is in almost every way the opposite of a criminal.

Only when public opinion changes will politicians change the rules. Is it possible to change people’s minds? Yes, most people want to do the right thing.

We need to start with the word guilt. When most of us ask ourselves “is she guilty?”, we mean “did she do it and did she do it on purpose?” Included in that is “did she know what she was doing?” The law defines guilt more strictly in terms of “being responsible for her act.” This use to mean knowing it is wrong and being in control of your behavior - but post Hinckley it was changed to just knowing it was wrong.

Some states have already changed the language to the more appropriate option of “guilty and insane.” We need to have a national standard that reflects this more accurate and comprehensible description of severe mental illness and legal accountability. A verdict of guilty and insane should not be “you’re free to go, have a nice life.” It should mean you go to a locked psychiatric treatment facility where you are treated as long as necessary, perhaps for life. It should mean that if you are released it is under the close monitoring of the judicial system for as long as necessary, commensurate with the crime. Whatever enforcement monitoring is necessary to assure protection for all concerned is feasible and should be a mandatory component.

Another problem that unnecessarily made the Yates jury’s decision more difficult is that they were not allowed to know what would happen to her if they found her not guilty. For all they knew she could have walked out the front door. This is ostensibly so that they make their decision based strictly on the law (with all its nebulous and abstract concepts). They should not be deciding based on the practical element of “what difference does it make what we decide?” Why not? Because despite the iconic balanced scales, the law is not about logic or fairness, it’s about “what are the facts and what is the law?”

In fairness, Andrea Yates did not meet the Texas law’s standard for criminal insanity. She knew what she was doing was against the law, and she knew she would be punished. She also knew it was against God’s law and the commandments. She believed that by killing her children she was sacrificing her life and her soul to save theirs. She felt responsible for them being bad kids (misbehaved) on the wrong path. In fact, Pastor Michael Woroniecki often quoted from the gospel of Mark, “whoever causes one of these little ones to stumble, it would be better for him if, with a heavy millstone hung around his neck, he had been cast into the sea.” She had attempted suicide twice because in her mind that would be protecting her children from her bad mothering. How ironic that it was the ultimate sacrifice of a mother for her beloved children.

Basically the jury decided - we don’t care what the law says, this woman was (and still is) crazy, psychotic. She is not a criminal - what she needs is help not punishment.

It’s hard to put yourself in someone else’s shoes. One of the best definitions of empathy that I’ve heard is: can you tell the other person’s story from their point of view? (which does not mean you agree with their thinking or that you approve of their behavior.) How can you imagine being insane? The closest I think you can get is to think about how your mind works when you are dreaming - random, weird, sometimes scary. That’s how a psychotic person’s mind works when they are awake. They cannot control their mind - it controls them.

What kind of a person is Andrea Yates? She is the opposite of a criminal. She was an R.N. She has been described by people who know her well as one of the most selfless and giving people they know. When her father was sick and dying, she’s the one who was taking care of him in addition to taking care of her own five kids. When someone in the neighborhood was sick, she’s the one that prepared meals for them. Her ex-husband, who also lost his five kids, has never wavered in his support for her. He knows that she killed the children out of love and psychosis. What possible criminal motive could she have had? She didn’t try to get away with anything - she immediately called the police.

To really understand the ordeal that she and her whole family went through you should read the excellent book, Are You There Alone?: The Unspeakable Crime of Andrea Yates, by Suzanne O’Malley. They went through years of suffering and medical mismanagement. It has been known for at least 10 years that postpartum psychosis is a rare complication of childbirth and that it is almost always a form of bipolar disorder (the old term is manic depressive).

For centuries throughout the world, new mothers in a state of insanity have murdered their babies. The U.S., to my knowledge, may be the only industrialized advanced country that considers it murder.

We have known for years that patients with bipolar disorder are made worse by antidepressants - unless they are on adequate doses of mood stabilizers or at least on an antipsychotic. Yates had been on Haldol (an older harsher antipsychotic - but more acceptable to insurance companies because it’s in generic), but even that had been stopped. When she killed her children she was on just antidepressants. Whose fault is that?

Yates had been hospitalized on several occasions, but kicked out early due to insurance company pressure. The hospital unit she was last treated on was for drug addicts, where she was forced to go to group therapy and lectures about addiction. How useful was that? Whose fault was that?

Ironically again, she was a devout Christian who was unduly influenced by a lunatic minister who repeatedly burdened her with guilt and impossible standards by which she was to judge the mental/spiritual health of her children. The thread of extreme fundamentalism seems to appear too often in cases where mothers kill their babies.

Could the influence of extreme “spirituality” on someone with the genetics of bipolar disorder contribute to the loss of control by the rational part of the mind?

There is no question that five children tragically lost their lives, but who/what is really to blame? Is it the system, the minister, the insurance companies, the hospitals, the doctors? Some people blame the ex-husband. When I review all the facts I see him as one of the victims. Maybe he relied too much on faith. Maybe he didn’t scream loud enough when her treatment wasn’t working. But I believe he did everything he knew to do.

If all the discussion and TV specials (that attract a lot of viewers and make the networks a lot of money) ultimately lead to greater understanding, then a change in public attitudes and a change in laws might happen. Then the death of five children will not have been in vain. The best outcome would be for a greater awareness to lead to early diagnosis and effective treatment for postpartum psychosis so that future babies aren’t the victims of Dark Age mentality in the 21st century.

Guilt is feeling bad because you hurt someone else. Shame is feeling bad because you don’t live up to your own standards and values. Shame is what the system should feel for not protecting the five children of Andrea Yates. Shame is what the system should feel for letting her sink deeper and deeper into the depths and torture of psychotic hell. Shame is what the system should feel for rubbing her nose in it over and over and parading her around like a freak show exhibit.

Shame on everyone who contributed to the problem or exploited it for personal or financial gain.

Andrea Yates, her ex-husband Rusty, and all their family and friends will suffer the rest of their lives because babies of mothers with postpartum psychosis don’t have a lobby group and can’t vote. Let’s change the system!

Let me know what you think by adding your comments.

Treating Fibromyalgia

Tuesday, July 25th, 2006

Question:

I am taking cymbalta, concerta and ambien - this week to substitute daytrana - for fibromyalgia. Key problems are sleep, pain, mental fog, low energy to the level of cfs. Is it standard treatment to use a stimulant drug for this condition? I have relief in all areas when taking the meds - but the energy and motivation are still laggin behind. (this question originally appeared as a comment on the article Determining the Best Stimulants.)

– Linda

Answer:

Strictly speaking, there is no standard treatment for Fibromyalgia. I’m not aware of any treatment having formal FDA approval. Cymbalta does have some positive controlled studies and Eli Lilly may be applying for approval.

Low thyroid is a common problem associated with fibromyalgia (see Thyroid Facts and Myths).

Stimulants are frequently used for chronic fatigue although they are not FDA approved for this. You are on a good combination of meds. If you are taking Cymbalta early in the day, switching to bedtime might help.

There are multiple options that could help motivation and energy levels:

  • Increasing Concerta
  • Increasing Cymbalta
  • Adding Wellbutrin XL

Of course, you would need to discuss options with your doctor. It’s usually best to make only one change at a time.

Good luck!

Dr. Jones